Why don't the Farrellys/MGM talk to Paymer, Michael Chiklis, and Paul Ben Victor? I always thought these three would be the best bet; they've got the look and the talent. Just my three cents...
The Farrelly project remains what it set out to be back in 2001...
an "updated-for-the-21st-century" version of the Stooges, focusing on bodily functions for sight gags.
Warner Bros. passed after a couple years, the Farrellys weren't able to privately produce it, an independent film corp. did nothing with it for a couple years... it's now 2009 and MGM/UA has signed on, while dealing with serious financial issues and a bleak outlook.
Paymer, Chiklis, Victor... Carrey, Del Toro, Penn... past names attached to this crappola included Jack Black, Russell Crowe, Johnny Depp... it doesn't matter.
If you take a pile of manure and adorn it with it tinsel... when you're done, all you've got is shit and dirty, smelly tinsel.